How to use Oncozar:
Use aseptic techniques during the reconstitution and any further dilution of Oncozar for intravenous infusion administration. Calculate the dose and the number of Oncozar vials needed. The usual dose of Oncozar is 1000-1250 mg for every square meter of your body’s surface area. Your height and weight are measured to work out the surface area of your body. Your doctor will use this body surface area to work out the right dose for you. This dosage may be adjusted, or treatment may be delayed depending on your blood cell counts and on your general condition.
Oncozar 200 mg: Reconstitute each 200 mg vial with 5 ml of 9 mg/ml (0.9%) sodium chloride solution for injection, without preservative, resulting in a solution containing 38 mg/ml gemcitabine. The total volume after reconstitution is 5.26 ml.
Oncozar 1 g: Reconstitute each 1 g vial with 25 ml of 9 mg/ml (0.9%) sodium chloride solution for injection, without preservative, resulting in a solution containing 38 mg/ml gemcitabine. The total volume after reconstitution is 26.3 ml.
Reconstituted Oncozar is a clear, colorless solution. The reconstituted solution should be inspected visually for particulate matter and discoloration prior to administration. If turbidity is observed, do not administer. Prior to administration, reconstitute solution should be diluted with 0.9% Sodium Chloride Injection, USP to a minimum final concentration of at least 0.1 mg/ml.
Chemical and physical in-use stability has been demonstrated for 24 hours at 20°C to 25°C. From a microbiological point of view, the product should be used immediately. If not used immediately, in-use storage times and conditions prior to use are the responsibility of the user and would normally not be longer than 24 hours at room temperature, unless reconstitution/dilution has taken place in controlled and validated aseptic conditions.
If the prepared solution comes into contact with the eyes, this may cause serious irritation. The eyes should be rinsed immediately and thoroughly with water. If there is lasting irritation, a doctor should be consulted. If the solution is spilled on the skin, rinse thoroughly with water.
You will always receive Oncozar by infusion into one of your veins.
The infusion will last approximately 30 minutes. How frequently you receive your Oncozar infusion depends on the type of cancer that you are being treated for.
If you have further questions on the use of this product ask your doctor or pharmacist.