Possible side effects

Like all medicines, this medicine can cause side effects although not everybody gets them. This medicine may also affect the results of some blood tests.

Very common side effects (may affect more than 1 in 10 people):

Diarrhea, feeling sick (nausea), feeling weak or tired (fatigue),pain (including mouth pain, abdominal pain, headache, bone pain, tumor pain), hair loss (alopecia), flushed or painful palms or soles (hand foot skin reaction), itching or rash, throwing up (vomiting), bleeding (including bleeding in the brain, gut wall and respiratory tract; hemorrhage), High blood pressure, or increases in blood pressure (hypertension),infections, loss of appetite (anorexia), constipation, joint pain (arthralgia), fever, weight loss, dry skin.

Common side effects (may affect up to 1 in 10 people):

Flu-like illness, indigestion (dyspepsia), difficulty swallowing (dysphagia), inflamed or dry mouth, tongue pain (stomatitis and mucosal inflammation), low calcium levels in the blood (hypocalcaemia), low potassium levels in the blood (hypokalemia), low blood sugar level (hypoglycemia), muscle pain (myalgia), disturbed sensations in fingers and toes, including tingling or numbness (peripheral sensory neuropathy), depression, erection problems (impotence), altered voice (dysphonia), acne, inflamed, dry or scaly skin that sheds (dermatitis, skin desquamation), heart failure, heart attack (myocardial infarction) or chest pain, tinnitus (ringing sound in the ear), kidney failure, abnormally high levels of protein in the urine (proteinuria), general weakness or loss of strength (asthenia), decrease in the number of white blood cells (leucopenia and neutropenia), decrease in the number of red blood cells (anemia), low number of platelets in the blood (thrombocytopenia), inflammation of hair follicles (folliculitis), underactive thyroid gland (hypothyroidism), low sodium levels in the blood (hyponatremia), distortion of the sense of taste (dysgeusia), red in the face and often other areas of the skin (flushing), runny nose (rhinorrhea), heartburn (gastro esophageal reflux disease), skin cancer (keratoacanthomas/squamous cell cancer of the skin), a thickening  of the outer layer of the skin (hyperkeratosis), a sudden, involuntary contraction of a muscle (muscle spasms).

Uncommon side effects (may affect up to 1 in 100 people):

Inflamed stomach lining (gastritis), pain in the tummy (abdomen) caused by pancreatitis, inflammation of the gall bladder and/or bile ducts, yellow skin or eyes (jaundice) caused by high levels of bile pigments (hyperbilirubinemia), allergic like reactions (including skin reactions and hives), dehydration, enlarged breasts (gynecomastia), breathing difficulty (lung disease), eczema, overactive thyroid gland (hyperthyroidism), multiple skin eruptions (erythema multiform), abnormally high blood pressure, holes in the gut wall (gastrointestinal perforation), reversible swelling in the rear part of the brain that can be associated with headache, altered consciousness, fits and visual symptoms including visual loss (reversible posterior leukoencephalopathy), a sudden, severe allergic reaction (anaphylactic reaction).

Rare side effects (may affect up to 1 in 1,000 people):

Allergic reaction with swelling of the skin (e. G. Face, tongue) that may cause difficulty in breathing or swallowing (angioedema), abnormal heart rhythm (qt prolongation), inflammation of the liver, which may lead to nausea, vomiting, abdominal pain, and jaundice (drug induced hepatitis), a sunburn-like rash that may occur on skin that has previously been exposed to radiotherapy and can be severe (radiation recall dermatitis), serious reactions of the skin and/or mucous membranes which may include painful blisters and fever, including extensive detachment of the skin (stevens-johnson syndrome and toxic epidermal necrolysis), abnormal muscle breakdown which can lead to kidney problems (rhabdomyolysis), damage of the kidney causing them to leak large amounts of protein (nephrotic syndrome), inflammation of the vessels in the skin which may result in rash (leucocytoclastic vasculitis).

Not known side effects (frequency cannot be estimated from the available data):

Impaired brain function that can be associated with e.g. Drowsiness, behavioral changes, or confusion (encephalopathy), an enlargement and weakening of a blood vessel wall or a tear in a blood vessel wall (aneurysms and artery dissections).

You might have any of these symptoms and/or conditions. You must tell your doctor as soon as possible when you start experiencing any of these side effects.