HOW TO USE Rinteca

Rinteca 100 actero pharma
Rinteca 100 Actero Pharma

How to use Rinteca

Administer Rinteca as a 90-minute intravenous infusion followed by LV and 5-FU. A reduction in the starting dose by one dose level of Rinteca may be considered for patients with any of the following conditions: prior pelvic/abdominal radiotherapy, performance status of 2, or increased bilirubin levels. Dosing for patients with bilirubin >2 mg/dL cannot be recommended because there is insufficient information to recommend a dose in these patients.


Rinteca Injection must be diluted prior to infusion. Rinteca should be diluted in 5% Dextrose Injection, USP, (preferred) or 0.9% Sodium Chloride Injection, USP, to a final concentration range of 0.12 mg/mL to 2.8 mg/mL. Other drugs should not be added to the infusion solution.

The solution is physically and chemically stable for up to 24 hours at room temperature and in ambient fluorescent lighting. Solutions diluted in 5% Dextrose Injection, USP, and stored at refrigerated temperatures (approximately 2° to 8°C, 36° to 46°F), and protected from light are physically and chemically stable for 48 hours.


Care should be exercised in the handling and preparation of infusion solutions prepared from Rinteca Injection. The use of gloves is recommended. If a solution of Rinteca contacts the skin, wash the skin immediately and thoroughly with soap and water. If Rinteca contacts the mucous membranes, flush thoroughly with water. Several published guidelines for handling and disposal of anticancer agents are available.


Rinteca Injection is contraindicated in patients with a known hypersensitivity to the drug or its excipients.